Tahlehelo e Phahameng ea Boima ho Tirzepatide e Hokela ho Lintlha tse Supileng

Har'a batho ba 3188 ba nang le lefu la tsoekere la mofuta oa 2 ba neng ba khomaretse mofuta oa bona oa tirzepatide (Mounjaro, Lilly) litekong tse 'ne tsa bohlokoa tsa moemeli, kotara e fihletse bonyane 15% ho fokotsa boima ba' mele ea bona kamora libeke tse 40-42 tsa kalafo, 'me bafuputsi ba fumane mefuta e supileng ea motheo e neng e amana haholo le boemo bo phahameng ba boemo bona ba tahlehelo ea boima ba' mele.

"Liphumano tsena li thusa ho tseba hore na ke batho ba mofuta ofe ba nang le lefu la tsoekere la mofuta oa 2 ba nang le monyetla oa ho fokotsa boima ba 'mele ka ho ntlafatsa maemo a kotsi a lefu la pelo le tirzepatide," ho boletse bangoli.

MOSEBETSI:

• Bafuputsi ba ile ba etsa tlhahlobo ea post hoc ea data e bokelletsoeng ho tsoa ho kakaretso ea batho ba 3188 ba nang le lefu la tsoekere la mofuta oa 2 ba neng ba latela mokhoa oo ba o abetsoeng oa tirzepatide bakeng sa libeke tse 40-42 ho e 'ngoe ea liteko tse' nè tsa bohlokoa tsa moemeli: SURPASS-1, SURPASS- 2, SURPASS-3, le SURPASS-4.
• Bafuputsi ba ne ba rerile ho tseba esale pele ho fokotseha ha boima ba 'mele bonyane 15% ka phekolo ea tirzepatide leha e le efe ea litekanyetso tse tharo tse lekiloeng - 5 mg, 10 mg, kapa 15 mg - tse neng li tsamaisoa ka ente e ka tlas'a letlalo hang ka beke.
• Liteko tsohle tse 'ne tse faneng ka data li thibetse kalafo e le 'ngoe e neng e tla khothalletsa ho theola boima ba' mele, 'me batho ba kenyellelitsoeng tlhahlobong ha baa ka ba fumana meriana ea pholoso bakeng sa ho laola glycemia.
• Tekanyo e ka sehloohong ea katleho lithutong tsohle tse 'nè e ne e le bokhoni ba tirzepatide ho ntlafatsa taolo ea glycemic (e lekantsoeng ke boemo ba A1c) ha e bapisoa le placebo, semaglutide (Ozempic) 1 mg SC hang ka beke, insulin degludec (Tresiba, Novo Nordisk), kapa insulin glargine ( Basaglar, Lilly).

TSA TSAU-TSAU:

• Har'a batho ba 3188 ba ileng ba lula ba khomaretse mokhoa oa bona oa tirzepatide bakeng sa libeke tsa 40-42, 792 (25%) e bile le phokotso ea boima ba bonyane 15% ho tloha qalong.
• Litlhahlobo tse ngata tsa li-covariate tsa mantlha li bonts'itse hore lintlha tsena tse supileng li ne li amana haholo le ≥15% ho theola boima ba 'mele: tekanyo e phahameng ea tirzepatide, ho ba mosali, ho ba oa morabe o Mosoeu kapa oa Asia, ho ba lilemong tse nyane, ho phekoloa ka metformin, ho ba le taolo e betere ea glycemic (e thehiloeng ho eona). ka A1c e tlase le tsoekere ea serum ea ho itima lijo e tlase), le ho ba le boemo bo tlase ba cholesterol ea non-high-density lipoprotein.
• Nakong ea ho lateloa, katleho ea bonyane ho fokotsa boima ba 'mele ea 15% ho ile ha amahanngoa haholo le phokotso e kholo ea A1c, boemo ba tsoekere ea serum e potlakileng, sekhahla sa letheka, khatello ea mali, boemo ba serum triglyceride, le boemo ba serum ea enzyme ea sebete ea alanine transaminase. .
  

  SEBELISA:

  "Liphumano tsena li ka fana ka tlhaiso-leseling ea bohlokoa ho lingaka le batho ba nang le lefu la tsoekere la mofuta oa 2 mabapi le monyetla oa ho fokotsa boima ba 'mele ka tirzepatide, hape e thusa ho bonts'a ntlafatso e ka bonoang mefuteng e mengata ea likotsi tsa lefu la pelo le tahlehelo ea boima ba 'mele e bakoang ke tirzepatide. ,” bangoli ba ile ba qetella ka tlaleho ea bona.