Sengoliloeng sena se tla u thusa ho khetha hore na ke efe eo u e loketseng haholoanyane ka ho araba lipotso tse latelang:
1.Ke phapang efe pakeng tsa tirzepatide le retatrutide?
2.Melemo ea tirzepatide ke efe?
3.Melemo ea retatrutide ke efe?
4.Ho bapisa Melemo ea Retatrutide le Tirzepatide
Phapano ke efe lipakeng tsa tirzepatide le retatrutide?
Phapang e kholo pakeng tsa tirzepatide le retatrutide e ka sebopeho sa bona.Tirzepatide ke motsoako oa likarolo tse tharo tse sebetsang - liraglutide, agonist ea glucagon-like peptide-1 (GLP-1);analogue ea oxyntomodulin;le analogue ea GLP-2.Retarutide, ka lehlakoreng le leng, e entsoe ka karolo e le 'ngoe e sebetsang - exenatide, e' ngoe ea GLP-1 e fetelletseng ka har'a manyeme.Lithethefatsi tsena ka bobeli li sebelisoa ho laola lefu la tsoekere la mofuta oa 2 ka ho eketsa tlhahiso ea insulin le ho theola maemo a tsoekere ea mali.Leha ho le joalo, retarutide e boetse e bontšitsoe ho fokotsa takatso ea lijo ka katleho ho feta tirzepatide feela ka lebaka la phello ea eona ho li-hormone tse amehang tlala le ho khora.Ka hona, e ka sebelisoa e le karolo ea mokhoa o kopanetsoeng oa ho laola boima ba 'mele bakeng sa batho ba nang le lefu la tsoekere ba nang le boima bo feteletseng kapa ba batenya.
Melemo ea tirzepatide ke efe?
①Taolo e ntlafalitsoeng ea glycemic le maemo a A1C, a lebisang ho bophelo bo botle ka kakaretso
Tirzepatide, e leng glucagon-like peptide 1 receptor agonist le GLP-1/glucose-dependent insulinotropic polypeptide (GIP) dual agonists, ke khetho e ncha ea phekolo bakeng sa lefu la tsoekere la mofuta oa 2.Ho fumanoe hore e sebetsa ho feta retatrutide ho ntlafatsa taolo ea glycemic le maemo a A1C.Litekong tsa meriana, tirzepatide e ne e amahanngoa le ho fokotseha ho hoholo ha maemo a A1C libeke tsa 12 ha ho bapisoa le retatrutide (-2.3% vs -1.8%), e leng se lebisang liphellong tse ntlafetseng tsa bophelo bo botle ho bakuli.
②Kotsi e fokotsehileng ea liketsahalo tsa pelo le methapo e kang lefu la pelo le stroke
Tirzepatide e fana ka mefuta e mengata ea melemo e ka bang teng ho batho ba kotsing ea liketsahalo tsa pelo le methapo e kang lefu la pelo le stroke.Phuputso ea 2019 e phatlalalitsoeng koranteng ea The Lancet e fumane hore batho ba noang tirzepatide ba na le kotsi e tlase haholo ea liketsahalo tse mpe tsa pelo (MACE) ha ba bapisoa le ba nkang retatrutide.Sena se kenyelelitse phokotso ea 35% ea MACE ha e bapisoa le retatrutide, e neng e sa bonts'a phapang e kholo ts'ebetsong likotsing tsa pelo.Nakong ea thuto, bafuputsi ba hlokometse hore bakuli ba nkang tirzepatide ba ile ba ba le maemo a tlase a lefu la methapo ea pelo, infarction ea myocardial, lefu la pelo le stroke ho feta ba sehlopheng sa retatrutide.Ho feta moo, barupeluoa ba nkileng tirzepatide le bona ba tlalehile maemo a ntlafetseng a taolo ea tsoekere ea mali le phaello e tlase ea boima ba 'mele ha e bapisoa le ba nkang retatrutide.Qetellong, ho bohlokoa ho ela hloko hore batho ba noang tirzepatide ha baa ka ba sireletsoa feela ho MACE empa hape ba bile le phokotseho ea maemo a HbA1c (letšoao la tšenyo ea nako e telele ea lefu la tsoekere) le liperesente tsa mafura a 'mele ha li bapisoa le maemo a mantlha.Qetellong, liphetho tsena li supa monyetla oa hore tirzepatide e fokotse liketsahalo tsa pelo le methapo e amanang le lefu la tsoekere la mofuta oa 2 le ho fana ka melemo e meng e amanang le sebopeho sa 'mele.
Boima bo tlase ba 'mele ha bo bapisoa le retatrutide, e ka thusang ho fokotsa kotsi ea mafu a amanang le botenya
Tirzepatide e na le melemo e mengata ha e bapisoa le retatrutide, haholo-holo ha ho tluoa tabeng ea boima ba 'mele.Liphuputso li fumane hore tirzepatide e ka fella ka phokotso e kholo ea boima ba 'mele ho feta retatrutide ka nako e telele.Sena se ka bakoa ke bokhoni ba eona ba ho susumetsa ts'ebetso ea li-receptor tsa GLP-1 le ho khothaletsa ho khora.Ho feta moo, tirzepatide e fumanoe e fokotsa mafura a mpeng ho feta retatrutide, e ka thusang ho fokotsa kotsi ea lefu la tsoekere, mafu a pelo le mafu a mang a amanang le botenya.Ho feta moo, tirzepatide e bontšitsoe ho fokotsa maemo a tsoekere ea mali ka katleho ho feta retatrutide.Litlamorao tsena ha li kopane li ka ntlafatsa liphetho tsa bophelo bo botle ka kakaretso tse amanang le botenya le ho se sebetse hantle ha metabolism.
③Maemo a matla a eketseha ka lebaka la ntlafatso ea metabolism ea glucose
O mong oa melemo ea mantlha ea ho nka tirzepatide ke bokhoni ba eona ba ho eketsa maemo a matla ka lebaka la ntlafatso ea metabolism ea tsoekere.Lebaka ke hobane li-agonists tsa GLP1 receptor li rata mosebetsi oa tirzepatide ka ho susumetsa ho lokolloa ha insulin ho latela maemo a phahameng a tsoekere ea mali.Ka ho eketsa tlhahiso ea insulin le ho ntlafatsa metabolism ea tsoekere, 'mele o ka sebelisa tsoekere e ngata bakeng sa mafura mme sena se ka lebisa ho eketseha ha matla.Ntle le moo, GLP1 receptor agonists le eona e ka fokotsa takatso ea lijo, e lebisang ho fokotseng takatso ea lijo le taolo e ntlafalitsoeng ea boima ba 'mele.
Melemo ea retatrutide ke efe?
Retatrutideke moriana oa nako e telele o nang le ente e sebelisoang ho phekola lefu la tsoekere la mofuta oa 2.E amohetsoe ke US Food and Drug Administration (FDA) molemong ona.Melemo ea retatrutide e mengata, e etsa hore e be khetho e ntle har'a meriana e meng ea lefu la tsoekere.
Ha e qala, retatrutide e sebetsa kapele hang ha e kentsoe 'me litlamorao tsa eona li ka utloahala nakong ea lihora tse 24 tsa tsamaiso.Sena se etsa hore e sebetse ka potlako ho feta liente tse ling tsa nako e telele tse kang tirzepatide, tse ka nkang libeke tse 'maloa pele liphello leha e le life tse hlokomelehang li bonoa maemong a tsoekere ea mali.
Ho phaella moo, liphuputso li bontšitse hore retatrutide e atleha ho fokotsa maemo a A1C ho batho ba nang le lefu la tsoekere la mofuta oa 2 ha ba nkiloe hammoho le liphetoho tsa lijo le boikoetliso.Liteko tsa bongaka li boetse li bonts'itse hore retatrutide e thusa ho fokotsa maemo a tsoekere a potlakileng le taolo ea glycemic ka kakaretso ho basebelisi ha e bapisoa le placebo.Maemong a mang, batho ba sa kang ba fumana molemo ho tsoa meriana ea lefu la tsoekere ea molomo ba bile le litholoana tse atlehileng ka kalafo ea retatrutide.
Qetellong, e 'ngoe ea melemo e meholo ka ho fetisisa ea retatrutide ke mokhoa oa eona oa tsamaiso o bonolo;e hloka ente e le 'ngoe feela ka beke ho fapana le liente tse ngata tsa letsatsi le letsatsi joalo ka liphekolo tse ling tse ngata tsa lefu la tsoekere.Sena se ka etsa hore ho hlokomela lefu la tsoekere ho be bonolo haholo le ho thusa ho ntlafatsa boikamahanyo ba mokuli ho leano la kalafo ha nako e ntse e ea.
Ho bapisa Melemo ea Retatrutide le Tirzepatide
Ha ho tluoa tabeng ea katleho, retatrutide e bontšitsoe ho fokotsa maemo a HbA1c ka 1.9-2.4%, ha e bapisoa le Tirzepatide e fokotsang maemo a HbA1c ka 1.5-2%.Meriana ena ka bobeli e boetse e na le litla-morao tse tšoanang, tse kang ho nyekeloa ke pelo le hlooho.Leha ho le joalo, batho ba bang ba ka 'na ba fumana hore ba na le litla-morao tse fokolang ka Retatrutide ho feta ka Tirzepatide ka lebaka la litlhoko tsa eona tse tlaase.
Mabapi le polokeho, retarutide ka kakaretso e mamelloa hantle ha e sebelisoa ka litekanyetso tse khothaletsoang 'me ha e ekelle kotsi ea hypoglycemia kapa e baka boima ba' mele joalo ka liphekolo tse ling tsa lefu la tsoekere.Ka lehlakoreng le leng, Tirzepatide e na le kotsi e kholo ea karabelo ea sebaka sa ente ka lebaka la boholo ba eona.Ho feta moo, haeba e nooa ka tekanyo e feteletseng e ka baka hypoglycemia e matla le boima ba 'mele.
Ka kakaretso, retarutide le tirzepatide ke likhetho tse sebetsang tsa ho laola lefu la tsoekere la mofuta oa 2 empa e ka ba tse loketseng bakuli ba itseng ho latela litlhoko tsa bona.Retarutide e fana ka ts'ebetso e ntle e nang le litla-morao tse fokolang ha e ntse e bolokehile ho litekanyetso tse khothalletsoang;leha ho le joalo, Tirzepatide e ka fana ka phokotso e kholoanyane maemong a HbA1c empa hape e ka ba le kotsi e kholo ea litlamorao tse mpe haeba e sa sebelisoe hantle.Qetellong, ke habohlokoa ho buisana le ngaka ea hau e le hore u etse qeto ea hore na ke khetho efe ea phekolo e molemo bakeng sa hau ho latela maemo a hao a khethehileng le lipakane tsa bophelo bo botle.
Qala kalafo ea hau ea tirzepatide le semaglutide ho LianFu
Nako ea poso: Mar-18-2024